HIPRAGUMBORO GM97
Intermediate PLUS live vaccine against Gumboro disease, in oral lyophilisate suspension
COMPOSITION PER DOSE:
Live infectious bursal disease virus strain GM97 102 - 103 EID50 HIPRAGUMBORO GM97 is composed of freeze-dried Infectious Bursal Disease Virus, strain GM97, containing excipients, which induces the development of active immunisation of fully susceptible broilers against Gumboro Disease.
INDICATIONS:
Chickens: For active immunisation of broilers with insignicant levels of maternally derived antibodies (ELISA of 500 or below) to reduce mortality, clinical signs and lesions of Gumboro disease. Such birds can be vaccinated from one day of age. The onset of immunity is 14 days post vaccination and the duration 43 days post vaccination.
DOSAGE: 1 dose/bird.
ADMINISTRATION ROUTE: Oral.
Break the vacuum inside the vial by inoculation of 10 ml of drinking water without chlorine or disinfectants. Shake gently until complete resuspension of the freeze-dried powder before administration.
Posology:
Serologically negative birds can be vaccinated from one day of age. The optimum age for vaccination may be calculated using the level of maternal antibody in the chicks at day old (Kouwenhoven’s formula) by testing at least 18 birds (preferably 24) of the ‑ock according to the following table. All birds should be given a single vaccination only.
Method of administration:
The volume of water for reconstitution depends on the age of the birds and the management practice. Generally, 2 litres of water per 1,000 broilers for every day of age are needed. Hence, 1,000 14 day broilers would need 28 litres of water to reconstitute the 1,000 doses of vaccine. If the birds have higher or lower water requirements, adjust the volumes accordingly. The way in which this vaccine is administered is critical. The following management considerations have been found to improve the vaccine intake: Water should be withheld for 1-2 hours before vaccination to ensure that all reconstituted vaccine is consumed within 1-2 hours.
For bell drinkers: go round the house emptying and cleaning the drinkers during the water withholding period. Mix up the vaccine according to the recommendations and at the end of the water withholding period go round all the drinkers and ll them with water containing vaccine.
For nipple drinkers: a considerable amount of residual water may remain in the lines after the water withholding period. It is recommended to drain the lines and load them with water which contains vaccine before allowing the birds to have access to the nipples. Mix up the vaccine and apply to the tank. Calculate the volume that is left in the tank below the outlet valve and be sure to take this volume of water into account when calculating the number of doses to be added. Always make sure that there is food available when vaccinating (birds will not drink if they have no food to eat). Turn on mains water when all the water containing vaccine has been consumed.
WITHDRAWAL PERIOD:
Zero days.
CONTRA-INDICATIONS:
Do not use in chickens with detectable levels of maternal antibodies (ELISA titres higher than 500).Do not mix with any other vaccine or immunological product. Do not use in layers and breeders. Do not vaccinate sick birds.
UNDESIRABLE EFFECTS:
The administration of a single dose causes lymphocyte depletion in the bursa of Fabricius (in 50-75% of the follicles). Lymphocyte repopulation is observed from 14 days post vaccination onwards, at 28 days post vaccination there is still some depletion remaining (5-25% of follicles). This lymphocyte depletion does not result in an immunosuppressive effect.
SPECIAL PRECAUTIONS FOR USE:
- Due to its residual pathogenicity to the bursa the vaccine should be used only in areas contaminated with vvIBDV, except for infected ‑ocks showing clinical signs.
- Once reconstituted, administer the vaccine within a maximum of one hour.
- Do not use water with chlorine or disinfectants.
- The vaccine strain spreads to unvaccinated chickens.
- Store at +2 to +8 ºC, protected from light.
- Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.
PRESENTATION:
Pack with 10 vials of 1,000 doses.
Pack with 10 vials of 2,500 doses.
Pack with 10 vials of 5,000 doses.